Gentian Extract.10:1.Gentian Root Extract.Chinese Gentian Extract.Gentiopicrin,Gentiopicroside.CAS.NO:20831-76-9.M.F.:C16H20O9

Formula: C16H20O9.M.W.:356.325 g/mol

Synonyms:(5R-trans)-6-(beta-D-Glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano(3,4-c)pyran-1-one;1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-,(5R-trans)-,20831-76-9,C09782,EINECS 244-070-2,Gentiopicrin,Gentiopicroside
Chemical Name:(5R-trans)-6-(beta-D-Glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano(3,4-c)pyran-1-one Gentiopicrin;Gentiopicroside; CAS Type 1 Name:1H,3H-pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-, (5R-trans)-



Botanical Source:Gentian consists of the dried rhizomes and roots of following:Gentiana manshurica Kitag.; Gentiana scabra Bge.; Gentiana triflora Pall.; Gentiana rigescens Franch.
Common Names&Synonyms:Radix Gentianae,Gentian,Gentiana Lutea,Chinese Gentian,Long Dan Cao,bitter root,bitterwort,pale gentian,yellow gentian,Bitterwort,Sampson''''''''''''''''s Snakeroot,Bitter Root, Bitterwort, Gall Weed, Gentiana, Gentianae radix, Pale Gentian, Stemless Gentian, Yellow Gentian, Wild Gentian. Gentiana lutea;Gentiana acaulis,Chinese Gentiana species,genus Gentiana,Gentiana manshurica,root of Gentiana macrophylla,Chinese gentian,Radix gentianae,Gentiana triflora,Gentiana lutea,Gentiana lutea ssp. symphyandra,

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Active constituents of Gentian(Radix Gentianae,Gentian root):

Major Effective content: gentiopicrin, C16H20O9, (1.37%~6.34%).
Synonyms of Gentiopicrin:Gentiopicrin,Gentiopicroside.

Gentian contains bitter substances such as the glycosides gentiopicrin and amarogentin. The bitter taste of these can be detected even when diluted 50,000 times. Besides stimulating secretion of saliva in the mouth and hydrochloric acid in the stomach, gentiopicrin may protect the liver. Gentian is used to treat poor appetite and indigestion. An open study shows that gentian tincture inhibits the feeling of fullness after eating, suggesting it could improve poor appetite
Constituents of Gentian root:


The dried Gentian root of commerce contains Gentiin and Gentiamarin, bitter glucosides, together with Gentianic acid (gentisin), the latter being physiologically inactive. Gentiopicrin, another bitter glucoside, a pale yellow crystalline substance, occurs in the fresh root, and may be isolated from it by treatment with boiling alcohol. The saccharine constituents of Gentian are dextrose, laevulose, sucrose and gentianose, a crystallizable, fermentable sugar. It is free from starch and yields from 3 to 4 per cent ash.
Constitution in brief: Glycosides (gentiopicroside and amarogentin are primarily responsible for its bitter taste). Alkaloids. Flavonoids. Terpenes. Minerals. Vitamins.
Constituents of Gentian root: bitter principles of secoiridoid types (gentiopicrin, amarogentin, sweroside, swertiamarin); alkaloids (gentianine, gentialutine); oligosaccharides (gentianose); triterpenes; sugars (gentianose, gentiobiose), sucrose; polysaccharides (inulin, pectin); xanthones (gentisin, gentisein, isogentisin, gentioside, which impart the yellow colour to the root); phenolic acids (gentisic, caffeic, protocatechuic and others); traces of a complex volatile oil.
More details of Constitution:1,3,7-trimethoxyxanthone; 1-hydroxy-3,7-dimethoxyxanthone;1-o-primverosyl-7-oxy-3-methoxyxanthone; 2,3'''''''''''''''',4,6-tetrahydroxybenzophenone;7-o-primverosyl-1-oxy-3-methoxyxanthone; alpha-terpineol; aluminum (291 ppm);amarogentin (500-1200 ppm); ascorbic-acid (183 ppm); caffeic-acid;calcium (8140 ppm); carvacrol; chromium (13 ppm); cis-linalyl-oxide; cobalt (14 ppm); gentialutine; gentiamarin; gentianine (6000-8000 ppm); gentianose; gentiin; gentiobiose; gentiodise; gentioflavoside; gentiopicrin (11400-35000 ppm); gentioside; gentisein; gentisic-acid; gentisin; inulin; iron (370 ppm); isogentisin; limonene; linalol; magnesium (2740 ppm); manganese (23 ppm); mangiferin; niacin; nicotinic-acid; nicotinic-acid-amide; oxycinnamic-acid; pectin; phosphorus (2700 ppm); potassium (8770 ppm); protein (138000 ppm); protocatechuic-acid; riboflavin (2.1 ppm); saccharose; selenium; sinapic-acid; sodium (41 ppm); sucrose; swertiamarin; syringic-acid; thiamin (48 ppm); tin (40 ppm); zinc (29 ppm). ppm = parts per million.
Glycosides known as amarogentin and gentiopicrin are primarily responsible for the bitter taste of gentian. In addition, the plant contains several alkaloids (mainly gentianine and gentialutine), xanthones, triterpenes, and sugars. Aside from its action as a bitter stomachic, none of the other purported effects is well documented in human beings. Some experiments on small animals indicate that gentian may increase the secretion of bile; the alkaloid gentianine also exhibits anti-inflammatory properties.
Amarogentin - Although present in much smaller quantities than gentiopicroside, amarogentin is the constituent largely responsible for the bitterness of gentian. It is 3,000 times more bitter than gentiopicroside, and, tasted at dilutions of 1 :50,000, it is possibly the most bitter substance on the planet.

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Medicinal Action and application of Gentian(Radix Gentianae,Gentian root):

Primary Uses: Appetite Loss, Circulation/poor, Gastric Disorders, Indigestion, Jaundice, Liver Disorders
Secondary Uses: Anemia, Blood Impurities, Colds, Constipation, Cramps/stomach, Diarrhea, Dysentery, Fevers, Gas, Gout, heartburn, Menstruation/absent, Nausea, Spleen Ailments, Urinary Problems, Worms, Wounds, Yeast Infections
Gentian root and other highly bitter plants have been used for centuries by herbalists in Europe as digestive aids (the well-known Swedish bitters often contain gentian). Other folk uses included topical application on skin tumors, decreasing fevers, and treatment of diarrhea.
Gentian increases the appetite, stimulates digestive juices, decreases intestinal inflammation, treats indigestion, heartburn, liver and spleen disorders, promotes menstruation, strengthens and builds the body, and is helpful for gout and arthritis. Do not use during pregnancy.
Gentian is one of the most useful of our bitter vegetable tonics. It is specially useful in states of exhaustion from chronic disease and in all cases of general debility, weakness of the digestive organs and want of appetite. It is one of the best strengtheners of the human system, and is an excellent tonic to combine with a purgative to prevent its debilitating effects. Many dyspeptic complaints are more effectually relieved by Gentian bitters than by Peruvian Bark. It is of extreme value in jaundice and is prescribed extensively.
Gentian is used to reduce fevers by cooling the system. Gentian contains a bitter principle, amarogentin , which stimulates the glands, including the adrenals and the thyroid. It helps in the production of bile, which can have a positive effect on the liver and gallbladder.
Gentian is also used to clean the bowels, stimulate the pancreas, stimulate circulation, aid in the digestive process and help with female problems. Historically, gentian has been used to treat wounds and taken internally for inflammation from arthritis, jaundice and a sore throat. It is considered a great tonic for strengthening the entire body.
Gentian root Strengthens the digestive organs, increases circulation and is good for female organs.
Gentian root is a stimulator of the general circulation, which in turn stregthens the total system.
Gentian root is a high in simple energy producing sugars and is beneficial to the digesting organs, the stomach, and pancreas, as well as being an aid to the well being of both the kidney and spleen.
Gentian root Anti-inflammatory used in treatment of arthritis

Widespread use of gentian as an appetite stimulant and digestive aid would seem to favor the herb as effective for these conditions. However, since it is normally consumed as an alcoholic beverage, it is difficult to separate the effects of gentian from those of alcohol, which are very similar, at least when the alcohol is consumed in moderate amounts. In normal individuals, gentian is unlikely to produce undesirable side effects; however, occasional headaches have been reported. Overdoses (greater than 0.1 to 2 g of the drug decocted in 150 ml of water, three times per day), could lead to nausea or vomiting. Use is contraindicated in gastric or duodenal ulcers and hyperacidity. Pahlow warns that the drug may not be tolerated well by those with very high blood pressure or by expectant mothers. Actually, these people should be very cautious about using any medication, herbal or otherwise.
Medicinal virtues:The virtues of both are similar. They resist putrefactions and poison and a more sure remedy to prevent the pestilence cannot be found. It strengthens the stomach, helps digestion, comforts the heart, and preserves it against Paintings and swoonings. The powdered dried root opens obstructions of the liver and restores the appetite.
The herb provokes urine and the terms exceedingly, and therefore should not be given to women with child. But it is profitable for those troubled with cramps and convulsions, to drink the decoction. This also breaks the stone and helps ruptures. To kill the worms, take half a dram (1g) of the powder in the morning in any convenient liquor. It will also instantly heal lites on cattle''''''''''''''''s udders.

Gentian (Gentiana lutea) Gentian has been used for centuries for weakened digestive ability due to a weakness in gastric secretion, bile production or pancreatic enzyme production. It is our standard treatment for loss of appetite, anorexia, flatulence and heartburn. It also is great for sugar cravings along with Gymnema. Its bitterness really increases salivation and vagal nerve function, so we''''''''''''''''ve successfully used it for people who have lost bowel function due to sluggish vagal nerve function.
Actions: The essential active principles are the bitter substances contained in the herb. These bring about a reflex excitation of the taste receptors, leading to increased secretion of saliva and the digestive juices. Gentian root is therefore considered to be not simply a pure bitter, but also a roborant and tonic. In animal experimentation there are indications that bronchial secretion is increased.
Assimilation of fats:Gentian''''''''''''''''s bitter glycosides gentiopicrin and amarogentin stimulate secretion of saliva in the mouth and hydrochloric acid in the stomach, and may also stimulate bile production, which aids in the body''''''''''''''''s assimilation of fats.
Gentian is one of the most useful of our bitter vegetable tonics. It is specially useful in states of exhaustion from chronic disease and in all cases of general debility, weakness of the digestive organs and want of appetite. It is one of the best strengtheners of the human system, and is an excellent tonic to combine with a purgative to prevent its debilitating effects. Many dyspeptic complaints are more effectually relieved by Gentian bitters than by Peruvian Bark. It is of extreme value in jaundice and is prescribed extensively.
Besides being unrivalled as a stomachic tonic, Gentian possesses febrifuge, emmenagogue, anthelmintic and antiseptic properties, and is also useful in hysteria, female weakness, etc. Gentian with equal parts of Tormentil or galls has been used with success for curing intermittent fever.
As a simple bitter, Gentian is considered more palatable combined with an aromatic, and for this purpose orange peel is frequently used. A tincture made with 2 oz. of the root, 1 oz. of dried orange peel, and ? oz. bruised cardamom seeds in a quart of brandy is an excellent stomachic tonic, and is efficacious in restoring appetite and promoting digestion. A favourite form in which Gentian has been administered in country remedies is as an ingredient in the so-called Stockton bitters, in which Gentian and the root of Sweet Flag play the principal part.


Other Uses of Gentian:

Orally, Long Dan Cao/Gentian is used for digestive disorders, such as loss of appetite, fullness, and flatulence. It is used orally for fever, for hysteria, to stimulate menstrual flow, as an anthelmintic, and antiseptic.
Topically, Long Dan Cao/Gentian is used for treating wounds and cancer.
Combination with European elder flower, verbena, cowslip flower, and sorrel, gentian is used orally for maintaining healthy sinuses and treating sinusitis. It is used in combination with other products for malaria.
In traditional medicine, Long Dan Cao/Gentian has been used orally for diarrhea, gastritis, heartburn, and vomiting.
Foods and Beverages, Long Dan Cao/Gentian is used as an ingredient.
In manufacturing, Long Dan Cao/Gentian is used in cosmetics.
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Products Specifications and Supplying Conditions:

Chinense Gentian P.E. 10:1; 4:1
Description: Chinense Gentian P.E.
Plant Part Used: Root
Extract Ratio: 4:1;10:1
Serie Code: R-003
Expiration Date: 18~24Months in Good Condition
Storage Stock: Bulk in Stock
Pricing Terms: C&F;CIF;DDU;DDP.
Delivery Arrange: Soonest on the Day Confirmed

Appearance Showing: Orange Yellow Fine Powder
Extracts State: Fine Crystal Powder
Mesh Size: 100% Pass 80 Mesh Screen
Color: Orange Yellow
Odor and Smell: Charateristics, Strong piquancy
Taste Sense: Flavour with Characteristics
Bulk Density: 0.50g/ml.

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