Red Peony Root Extract.Paeoniflorin 10%.20%.90%HPLC.CAS RN:23180-57-6.M.F.C23H28O11,Radix Paeonia Rubra.Chi Shao,Peony extracts

Paeoniflorin:
Basic Data:CAS RN:23180-57-6.
Molecular Formula:C23H28O11 Molecular Weight: 480.47
Synonyms:5beta-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1alpha(2H)-yl-beta-D-glucopyranoside

Botanical Description of Red Peony Root (Radix Paeonia Rubra.Chi Shao):

Historical or traditional use:Peony is an ancient, traditional Chinese herbal medicine. The plant was and is extensively cultivated as an ornamental plant as well. Peony is named for the mythical Greek figure Paeon, who was said to be a student of Aesculapius, the great physician. Paeon used the peony plant (various species also grow in Europe) to heal a wound for the god Pluto. This earned Aesculapius''''''''''''''''''''''''''''''''s jealous wrath, but Pluto saved Paeon from death by turning him into a peony plant.

Chi shao or red peony was used for bleeding or lack of blood movement, depending on how it was prepared. Moutan was also considered helpful for problems characterized by bleeding, such as nosebleeds, bleeding wounds, or menorrhagia (excessive menstrual bleeding).

Phytochemicals:Red Peony Root,White Peony Root and Paeoniflorin

Peony contains a unique glycoside called paeoniflorin. Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Paeoniflorin''''''''''''''''''''''''''''''''s major effect seems to be to calm nerves and alleviate spasm. One study has confirmed the efficacy of formula with peony and licorice for relieving muscle cramps due to cirrhosis of the liver, diabetes, and dialysis,approved for treatment of muscle cramps. Another formulation combines peony root with dong quai and four other herbs and has been found to effectively reduce symptoms of cramping and pain associated with dysmenorrhea (painful menses).

Paeoniflorin and peony extracts also enhance mental function in animal studies, suggesting a potential benefit for dementia. Human studies have not yet been conducted to confirm this theory.

Red peony root and moutan bark have both shown antioxidant activity in test tubes, likely due to the presence of paeoniflorin, proanthocyanidins, and flavonoids. Polysaccharides found in peony bark and root have shown an ability to stimulate immune cells in the test tube.

Animal studies have found that red peony root, alone or in combination with other Chinese herbs, could help prevent liver damage due to various chemical toxins. A crude extract of red peony root was shown in a small, preliminary trial to reduce liver fibrosis in some patients with chronic viral hepatitis. Other case studies published in Chinese have found red peony root helpful for people with viral hepatitis.

Crude red peony root extracts and combinations of these extracts with other Chinese herbs inhibit platelet aggregation, thrombosis, and excessive clotting in the test tube and in animals.A rabbit study found that peony was effective at lowering cholesterol levels in the aorta. A preliminary human study confirmed that peony could inhibit platelet clumping. This suggests that peony might be helpful for prevention of atherosclerosis. However, clinical studies are needed to confirm this effect.
One uncontrolled clinical trial reported that moutan bark could significantly lower blood pressure in people with hypertension.

Peony shows some weak estrogen-like effects, acting like a very weak anti-estrogen, particularly as part of the formula shakuyaku-kanzo-to. In a preliminary study, this formula was shown to improve fertility in women affected by polycystic ovary syndrome.

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